• Jackie L Whittaker, Clodagh M Toomey, Alberto Nettel-Aguirre, Jacob L Jaremko, Patricia K Doyle-Baker, Linda J Woodhouse, and Carolyn A Emery.
• Faculty of Rehabilitation Medicine, Department of Physical Therapy, University of Alberta, Edmonton, AB, CANADA.
• Med Sci Sports Exerc. 2019 Feb 1; 51 (2): 255-263.

PurposeActive youth are vulnerable to knee injury and subsequent osteoarthritis. Improved understanding of the association between health-related outcomes and history of joint injury could inform osteoarthritis prevention strategies. The purpose of this historical cohort study is to examine the association between youth sport-related knee injury and various clinical, physiological, behavioral, and functional health-related outcomes, 3-10 yr postinjury.MethodsParticipants included 100 individuals who experienced a youth sport-related knee injury 3-10 yr earlier and 100 age-, sex-, and sport-matched uninjured controls. Outcomes include the following: Knee Injury and Osteoarthritis Outcome Score (KOOS), Intermittent and Constant Osteoarthritis Pain Score, body mass index (BMI), fat mass index (FMI), weekly physical activity, estimated aerobic capacity, hip and knee muscle strength, and dynamic balance. Baseline characteristics were described. Multivariable regression models (95% confidence interval [CI]) were used to evaluate the association between injury history and each outcome, considering the influence of sex and time since injury.ResultsParticipant median age was 22 yr (range, 15-26 yr), and 55% were female. The injured group demonstrated poorer KOOS subscale scores, more total and intermittent pain, higher BMI (1.8 kg·m; 95% CI = 0.9-2.6), higher FMI (1.1 kg·m; 95% CI = 0.5-1.6), weaker knee extensor (-0.18 N·m·kg; 95% CI = -0.33 to -0.02) and flexor (-0.21 N·m·kg; 95% CI = -0.30 to -0.11) muscles, and poorer balance than controls. In the previously injured group, female sex was associated with poorer KOOS quality-of-life scores, knee flexor strength, and greater FMI, whereas longer time since injury was associated with poorer KOOS symptoms scores, knee extensor strength, and balance outcomes.ConclusionYouth that suffer a sport-related knee injury demonstrate on average more negative health-related outcomes consistent with future osteoarthritis compared with uninjured matched controls 3-10 yr after injury. These negative outcomes differ by sex and time since injury.

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