• Int. J. Hematol. · Nov 2020

    Case Reports

    Severe immune thrombocytopenic purpura in critical COVID-19.

    • Valérie Lévesque, Émilie Millaire, Daniel Corsilli, Benjamin Rioux-Massé, and François-Martin Carrier.
    • Department of Medicine, Université de Montréal, Montréal, Canada.
    • Int. J. Hematol. 2020 Nov 1; 112 (5): 746-750.

    AbstractCOVID-19 is a new disease with many undescribed clinical manifestations. We report herein a case of severe immune thrombocytopenic purpura (ITP) in a critical COVID-19 patient. A patient presented a severe episode of immune thrombocytopenia (< 10 × 109/L) 20 days after admission for a critical COVID-19. This thrombocytopenia was associated with a life-threatening bleeding. Response to first-line therapies was delayed as it took up to 13 days after initiation of intravenous immunoglobulin and high-dose dexamethasone to observe an increase in platelet count. COVID-19 may be associated with late presenting severe ITP. Such ITP may also be relatively resistant to first-line agents. Hematological manifestations of COVID-19, such as the ones associated with life-threatening bleeding, must be recognized.

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