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Randomized Controlled Trial Clinical Trial
Clonidine decreases postoperative oxygen consumption in patients recovering from general anaesthesia.
- L Delaunay, F Bonnet, and P Duvaldestin.
- Service d'Anesthésie Réanimation, Hôpital Henri Mondor, Créteil, France.
- Br J Anaesth. 1991 Oct 1; 67 (4): 397-401.
AbstractTwenty ASA I patients, undergoing thyroid surgery were allocated randomly to receive at the end of surgery either an isotonic saline solution or clonidine 2 micrograms kg-1 i.v. administered over 20 min. Oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured during recovery in patients breathing spontaneously with a head canopy system. Clonidine was found to attenuate the increase in VO2 and VCO2 associated with recovery from anaesthesia. The effect of clonidine was associated with a reduction in shivering. Sedative and analgesic properties of clonidine may also contribute to the reduction in metabolic demand during recovery from anaesthesia.
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