• Masaki Sato, Kei Inai, Mikiko Shimizu, Hisashi Sugiyama, and Toshio Nakanishi.
• Department of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
• Congenit Heart Dis. 2019 Mar 1; 14 (2): 167-175.

ObjectiveThe recognition of fluid retention is critical in treating heart failure (HF). Bioelectrical impedance analysis (BIA) is a well-known noninvasive method; however, data on its role in managing patients with congenital heart disease (CHD) are limited. Here, we aimed to clarify the correlation between BIA and HF severity as well as the prognostic value of BIA in adult patients with CHD.DesignThis prospective single-center study included 170 patients with CHD admitted between 2013 and 2015. We evaluated BIA parameters (intra- and extracellular water, protein, and mineral levels, edema index [EI, extracellular water-to-total body water ratio]), laboratory values, and HF-related admission prevalence.ResultsPatients with New York Heart Association (NYHA) functional classes III-IV had a higher EI than those with NYHA classes I-II (mean ± SD, 0.398 ± 0.011 vs 0.384 ± 0.017, P < .001). EI was significantly correlated with brain natriuretic peptide level (r = 0.51, P < .001). During the mean follow-up period of 7.1 months, Kaplan-Meier analysis showed that a discharge EI > 0.386, the median value in the present study, was significantly associated with a future increased risk of HF-related admission (HR = 4.15, 95% CI = 1.70－11.58, P < .001). A body weight reduction during hospitalization was also related to EI reduction.ConclusionsEI determined using BIA could be a useful marker for HF severity that could predict future HF-related admissions in adult patients with CHD.© 2018 Wiley Periodicals, Inc.

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