• Hang Shi, Zhi-Min Zhou, Zheng-Yuan Xu, Lei Zhu, Zan-Li Jiang, Lu Chen, and Xiao-Tao Wu.
• Department of Spine Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
• World Neurosurg. 2021 Jul 1; 151: e1044-e1050.

ObjectiveTo investigate the risk factors for increased surgical drain output after transforaminal lumbar interbody fusion (TLIF).MethodsPatients who underwent TLIF in a single center from June 2017 to January 2020 were included in this study. They were divided into the increased surgical drain output group and no increased surgical drain output group according to the boundary of the median drain output. Patients' demographic and clinical parameters were compared between the 2 groups. Risk factors for increased surgical drain output were identified by univariate and multivariate logistic regression analysis.ResultsThis study enrolled 368 patients who underwent TLIF. Among them, 187 patients had increased surgical drain output (drain output ≥50th percentile or 480 mL). Univariate analysis showed that age (P < 0.001), smoking status (P = 0.002), number of fused levels (P < 0.001), intraoperative blood loss (P < 0.001), intraoperative end plate injury (P < 0.001), administration of tranexamic acid (TXA) (P = 0.002), and surgical duration (P < 0.001) were significantly associated with increased surgical drain output. Multiple logistic regression analysis revealed that older age (P = 0.001), smoking (P = 0.005), more fused levels (P < 0.001), and intraoperative end plate injury (P = 0.017) were the independent risk factors, while administration of TXA (P = 0.012) was a protective factor.ConclusionsThis study showed that older age, smoking, more fused levels, and intraoperative end plate injury were the independent risk factors, while administration of TXA was a protective factor for increased surgical drain output after TLIF.Copyright © 2021 Elsevier Inc. All rights reserved.

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