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Randomized Controlled Trial Comparative Study
Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension.
- Isla S Mackenzie, Carmel M McEniery, Zahid Dhakam, Morris J Brown, John R Cockcroft, and Ian B Wilkinson.
- Clinical Pharmacology Unit, Addenbrooke's Hospital Box 110, Cambridge, CB2 0QQ United Kingdom.
- Hypertension. 2009 Aug 1; 54 (2): 409-13.
AbstractIsolated systolic hypertension is an important risk factor for cardiovascular disease and results primarily from elastic artery stiffening. Although various drug therapies are used to lower peripheral blood pressure (BP) in patients with isolated systolic hypertension, the effects of the 4 major classes of antihypertensive agents on central BP, pulse pressure (PP) amplification, and arterial stiffness in this condition are not clear. Fifty-nine patients over the age of 60 years with untreated isolated systolic hypertension (systolic BP > or =140 mm Hg and diastolic BP
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