• Adina E Draghici, Diane Potart, Joseph L Hollmann, Vivian Pera, Qianqian Fang, Charles A DiMarzio, Andrew Taylor J J Car... more diovascular Research Laboratory, Spaulding Rehabilitation Hospital, Cambridge, Massachusetts. , Mark J Niedre, and Sandra J Shefelbine. less
• Department of Bioengineering, Northeastern University, 260 Egan Research Center, 360 Huntington Ave, Boston, Massachusetts.
• J. Orthop. Res. 2018 Jan 1; 36 (1): 183-191.

AbstractBone blood perfusion has an essential role in maintaining a healthy bone. However, current methods for measuring bone blood perfusion are expensive and highly invasive. This study presents a custom built near-infrared spectroscopy (NIRS) instrument to measure changes in bone blood perfusion. We demonstrated the efficacy of this device by monitoring oxygenated and deoxygenated hemoglobin changes in the human tibia during and after exercise in able-bodied and in individuals with spinal cord injury (SCI), a population with known impaired peripheral blood perfusion. Nine able-bodied individuals and six volunteers with SCI performed a 10 min rowing exercise (functional electrical stimulation rowing for those with SCI). With exercise, during rowing, able-bodied showed an increase in deoxygenated hemoglobin in the tibia. Post rowing, able-bodied showed an increase in total blood content, characterized by an increase in total hemoglobin content due primarily to an increase in deoxygenated hemoglobin. During rowing and post-rowing, those with SCI showed no change in total blood content in the tibia. The current study demonstrates that NIRS can non-invasively detect changes in hemoglobin concentration in the tibia. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:183-191, 2018.© 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

16 keywords...

hide…