• Marko Ajduk, Ivana Tudorić, Mirko Sarlija, Predrag Pavić, Zrinka Oremuš, Rebeka Held, and Leonardo Patrlj.
• Department of Vascular Surgery, University Hospital Dubrava, Zagreb, Croatia. majduk@yahoo.com
• J. Vasc. Surg. 2011 Aug 1; 54 (2): 386-93.

ObjectiveTo find out whether routine carotid sinus nerve blockade with lidocaine during carotid endarterectomy under local anesthesia results in perioperative changes in blood pressure and heart rate.MethodsThis was a prospective, randomized, single-center study, conducted in a university hospital. A total of 120 patients undergoing carotid endarterectomy under local anesthesia were randomly assigned to three equal groups. Patients with previous carotid endarterectomy were excluded from the study. During the operation the carotid sinus area was infiltrated as follows: group 1 received 2 mL of 1% lidocaine; group 2 received 2 mL of 0.9% NaCl; and group 3 received no infiltration. The carotid sinus nerve was spared in all patients. Blood pressure and heart rate were invasively monitored during the operation and 12 hours postoperatively over the radial artery cannula. Preoperative values were calculated as a mean of three noninvasive measurements on the day before surgery. Data comprised of arterial blood pressures and heart rates from 32 time point measurements for each patient were analyzed.ResultsThere was no significant difference among the groups regarding the mean arterial blood pressures and mean heart rates during the follow-up period. There was no significant difference among groups regarding the number of patients that required vasoactive therapy at any time of measurement.ConclusionRoutine infiltration of carotid sinus area with 1% lidocaine during carotid endarterectomy performed under local anesthesia has no significant impact on mean arterial blood pressure and heart rate during the operative procedure and the following 12 postoperative hours.Copyright © 2011 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.

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