• Pietro Pepe, Davide D'Urso, Antonio Garufi, Giandomenico Priolo, Michele Pennisi, Giorgio Russo, Maria Gabriella Sabini, Lucia Maria Valastro, Antonio Galia, and Filippo Fraggetta.
• Urology Unit, Cannizzaro Hospital, Catania, Italy.
• In Vivo. 2017 May 1; 31 (3): 415-418.

AimTo evaluate the accuracy of multiparametric magnetic resonance imaging apparent diffusion coefficient (mpMRI ADC) in the diagnosis of clinically significant prostate cancer (PCa).Patients And MethodsFrom January 2016 to December 2016, 44 patients who underwent radical prostatectomy for PCa and mpMRI lesions suggestive of cancer were retrospectively evaluated at definitive specimen. The accuracy of suspicious mpMRI prostate imaging reporting and data system (PI-RADS ≥3) vs. ADC values in the diagnosis of Gleason score ≥7 was evaluated.ResultsReceiver operating characteristics (ROC) curve analysis gave back an ADC threshold of 0.747×10-3 mm2/s to separate between Gleason Score 6 and ≥7. The diagnostic accuracy of ADC value (cut-off 0.747×10-3 mm2/s) vs. PI-RADS score ≥3 in diagnosing PCa with Gleason score ≥7 was equal to 84% vs. 63.6% with an area under the curve (AUC) ROC of 0.81 vs. 0.71, respectively.ConclusionADC evaluation could support clinicians in decision making of patients with PI-RADS score <3 at risk for PCa.Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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