• Jihye Seo, Donghun Lee, and Hee-Geun Jo.
• Chung-Yeon Korean Medicine Hospital, Seo-gu, Gwangju.
• Medicine (Baltimore). 2019 Dec 1; 98 (50): e18345.

BackgroundPrimary dysmenorrhea is the most common gynecological disorder in women of reproductive age. In East Asia, traditional herbal medicines have been used for a long time to treat symptoms of primary dysmenorrhea. Dangguijagyag-san (DJS) is one of the most widely known traditional herbal medicine for primary dysmenorrhea. Although there was the previous systematic review of DJS, it had some limitations. To assess the effectiveness of DJS for primary dysmenorrhea and to update the previous review, this protocol was developed to conduct a systematic review and meta-analysis.MethodsWe will search the randomized controlled clinical trials of DJS for primary dysmenorrhea from inception to April 2019. The search database will be PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Oriental Medicine Advanced Searching Integrated System, Korean Traditional Knowledge Portal, Korean Medical Database, National Digital Science Library, and the China National Knowledge Infrastructure. Our 2 authors will perform the selection of studies, the extraction of data, and the quality assessment with risk of bias tool independently. To analyze the data, we will conduct the quantitative synthesis.ResultsWe will synthesize the data from selected studies and estimate the strength of the evidence DJS for the treatment of primary dysmenorrhea.ConclusionThis study will provide the scientific evidence of DJS.Systematic Review RegistrationPROSPERO registration number is CRD42019130768.

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