• Int. J. Tuberc. Lung Dis. · May 2012

    Population-based surveillance of extensively drug-resistant tuberculosis in Shandong Province, China.

    • X Li, H Wang, H Jing, Y Wang, C Yu, J Wang, Z Liu, E A Graviss, and X Ma.
    • Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, China.
    • Int. J. Tuberc. Lung Dis. 2012 May 1; 16 (5): 612-4.

    AbstractTo investigate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) in Chinese populations, we analyzed the drug resistance profiles of 1787 Mycobacterium tuberculosis isolates through a population-based surveillance project in Shandong Province, China. We found 330 (18.5%; 95%CI 16.1-20.3) isolates resistant to ≥1 first-line drug and 65 (3.6%; 95%CI 2.9-4.6) multidrug-resistant (MDR) isolates, of which 13 (20.0%; 95%CI 11.9-31.4) were XDR; 47/65 MDR-TB isolates (70.8%; 95%CI 58.2-81.4) were resistant to fluoroquinolones. Our results indicate that inadequate application of second-line anti-tuberculosis drugs has caused increased prevalence of XDR-TB in certain Chinese populations.

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