• O Rodríguez-Queraltó, F Formiga, A Carol, C Llibre, M Martínez-Sellés, F Marín, P Díez-Villanueva, J Sanchis, C Bonanad, M Corbí, J Aboal, J Angel Perez-Rivera, O Alegre, E Bernal, L Vicent, and A Ariza-Solé.
• Albert Ariza Solé. Cardiology Department. Bellvitge University Hospital, Feixa Llarga s/n. 08907. L'Hospitalet de Llobregat. Barcelona. Spain, Email address: aariza@bellvitgehospital.cat, Fax Number +34932607618; Telephone number +34932607924.
• J Nutr Health Aging. 2020 Jan 1; 24 (7): 723-729.

ObjectivesDiabetes mellitus (DM) and frailty are common in older patients with acute coronary syndromes (ACS). No data exists about its prognostic impact on long-term outcomes and their possible interaction in this setting.DesignObservational prospective study.SettingMulticenter registry conducted in 44 hospitals in Spain.ParticipantsConsecutive patients with ACS aged 80≥years.MeasurementsA comprehensive geriatric evaluation was performed during hospitalization, including frailty assessment by the FRAIL score. The impact of DM and frailty on the incidence of mortality/readmission at 24 months was analysed by a Cox regression model.ResultsA total of 498 patients were included (mean age 84.3 years). Prevalence of previous DM was 199/498 (40.0%). The rate of frail patients was 135/498 (27.1%). The incidence of mortality/readmission was higher frail patients (HR 2.49) (both p<0.001). In contrast, DM was not significantly associated to a higher rate of outcomes (HR 1.23, p=0.060) in the whole cohort. Among non-frail patients, patients with DM had a similar incidence of mortality or readmission (p=0.959). In contrast, among frail patients, DM was significantly associated with a higher incidence of events (HR 1.51, p=0.034).ConclusionsUnlike frailty status, DM was not associated to poorer long-term outcome in elderly patients with ACS. Among frail patients the presence of DM seems to provide additional prognostic information.

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