• AIDS · Nov 2017

    Serum suppression of tumorigenicity 2 level is an independent predictor of all-cause mortality in HIV-infected patients.

    • Rodolphe Thiébaut, Sophie Hue, Fabien Le Marec, Jean-Daniel Lelièvre, Michel Dupon, Emile Foucat, Estibaliz Lazaro, François Dabis, Pierre Duffau, Linda Wittkop, Mathieu Surenaud, Isabelle Pellegrin, Christine Lacabaratz, Fabrice Bonnet, Yves Lévy, and ANRS CO3 Aquitaine Cohort.
    • aBordeaux University, INSERM U1219, Bordeaux Population Health Research Center, INRIA Sistm bCentre Hospitalier Universitaire de Bordeaux, Bordeaux cINSERM U955, Paris Est Créteil University dGroupe Hospitalier Henri-Mondor Albert-Chenevier, Créteil, France. *Rodolphe Thiébaut and Sophie Hue cocontributing authors.
    • AIDS. 2017 Nov 13; 31 (17): 2355-2365.

    ObjectiveTo evaluate the predictive value of soluble suppression of tumorigenicity 2 (sST2), a decoy receptor of IL-33 involved in several inflammatory and immune diseases, for death in HIV infection.DesignPatients enrolled in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients, who had a plasma sample available in the biobank were systematically eligible.MethodssST2, soluble CD14 (sCD14) and IL-6 were measured using Luminex multiplex bead-based technology (R&D Systems) and a Bio-Plex 200 instrument (BioRad). Predictive capacities of sST2, sCD14, IL-6 and of the Veterans Aging Cohort Study clinical score at baseline on overall mortality were compared using multivariable Cox proportional hazards models.ResultsDuring a median follow-up of 7.2 years [interquartile range (IQR): 6.0; 7.9], 93 deaths from all causes (incidence rate 9.9 per 1000 patient-years; 95% confidence interval 7.9-11.9) were reported in 1414 patients. The median sST2 baseline concentration was 22.9 ng/ml (IQR: 17.7; 30.3) and was higher (30.8 ng/ml, IQR: 21.5; 42.1) in patients who died as compared with those who stayed alive (22.6 ng/ml; IQR: 17.5; 29.6) (P < 10). An increased risk of death of 21% for a concentration 10.0 ng/ml higher of sST2 remained after adjustment for sCD14, IL-6 and Veterans Aging Cohort Study score (adjusted hazard ratio: 1.21; P < 10). The predictive capacity of sST2 was confirmed in a validation cohort (n = 386, 31 deaths) with an improved area c-index from 0.804 without sST2 to 0.811 with sST2.ConclusionsST2 is a new valuable biomarker to evaluate the risk of all-cause mortality in HIV disease.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.