• Karel Van Keer, Jan Van Keer, João Barbosa Breda, Vahid Nassiri, Johan Van Cleemput, Luìs Abegão Pinto, Ingeborg Stalmans, and Evelien Vandewalle.
• Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.
• Acta Ophthalmol. 2019 Mar 1; 97 (2): e308-e312.

PurposeTo investigate the correlation between retinal vessel oxygen saturation and mixed venous oxygen saturation (SvO2-mixed ) and cardiac output (CO).MethodsRetinal arterial (SaO2-retinal ) and venous (SvO2-retinal ) oxygen saturation were measured non-invasively with dual-wavelength retinal oximetry in subjects receiving invasive measurements of SvO2-mixed and CO through right heart catheterization. Correlations were analysed using Spearman's rank correlation coefficients and linear regression models.ResultsFourteen patients (median age 62.7 years, range: 21-77) were included in the analysis. When adjusted for age, SvO2-retinal showed a positive correlation with SvO2-mixed (β = 0.80, p = 0.003). Retinal arteriovenous oxygen saturation difference was significantly correlated with the inverse of CO (Spearman's ρ = 0.59, p = 0.026).ConclusionThis pilot study provides proof of concept for the use of retinal oximetry as a non-invasive tool to assess systemic cardiovascular function.© 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

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