• T Tsuda, T Nakamura, Y Yamamoto, M Teramachi, T Kiyotani, Y H Lee, and Y Shimizu.
• Department of Artificial Organs, Research Center for Biomedical Engineering, Kyoto University, Japan.
• Ann. Thorac. Surg. 1999 Aug 1; 68 (2): 339-42.

BackgroundHuman amnion has useful biomedical applications because it contains a large amount of human collagen fibers. We prepared purified human collagen membrane (HCM) from human amnion and used it to develop a new sheet by combining it with synthetic bioabsorbable polyglycolic acid (PGA) mesh. We evaluated its efficacy in preventing air leakage from the lungs of dogs.MethodsIn 20 dogs, HCM-PGA sheet (n = 5), sheets using fibrin glue with a separate application method (n = 5), a mixed application method (n = 5), and fibrin glue alone (n = 5), were used as dressing materials after partial lung resection.ResultsThe HCM-PGA sheet using fibrin glue with a separate application method was shown to be significantly more effective by an air leakage pressure test than the other three methods. These results indicate that the HCM-PGA sheet is useful for preventing air leakage from the lung.ConclusionsThe HCM-PGA sheet is more effective than conventional fibrin glue for controlling postoperative air leakage.

27 keywords...

hide…