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- Louise Taber, Ellie He, and Steven R Ripa.
- Arizona Research Center, Phoenix, AZ 85023, USA.
- Pain Manag. 2017 Nov 1; 7 (6): 473-488.
AimLong-term safety and effectiveness of a once-daily, single-entity, extended-release formulation of hydrocodone bitartrate (HYD) for the treatment of moderate to severe noncancer and nonneuropathic pain among patients with and without concurrent depression/anxiety at baseline.Materials & MethodsPost hoc analysis.ResultsHYD demonstrated a safety profile consistent with μ-opioid agonists: Serious adverse events in 12% patients with depression/anxiety including four deaths; 6% without depression/anxiety including one death. All pain scores declined by ≥2 points and mean daily HYD dose remained stable in both subgroups.ConclusionMore serious adverse events occurred among patients with comorbid depression/anxiety at baseline than among those without. HYD provided stable and effective analgesia for 52 weeks among chronic pain patients with and without comorbid depression/anxiety at baseline.
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