• Dong-Dong Wang, Xiao-He Hou, Hong-Qi Li, Wei Xu, Ya-Hui Ma, Qiang Dong, Jin-Tai Yu, and Lan Tan.
• Department of Neurology, Qingdao Municipal Hospital, Qingdao University, China; Department of Neurology, Weifang Traditional Chinese Hospital, Weifang Medical University, China. Electronic address: love.pear@163.com.
• J Stroke Cerebrovasc Dis. 2020 Dec 1; 29 (12): 105363.

BackgroundInflammation occurs after acute ischemic stroke (AIS), and complement C1q is involved in inflammation. However, studies about the association of complement C1q with AIS are still rare. The aim of our study is to investigate the relationship between serum C1q concentration and the clinical severity of AIS.MethodsA total of 1294 patients were enrolled in our study, including 647 patients with AIS and 647 non-stroke controls. The infarction volume of AIS was assessed by the diameter of maximum transverse section (DMTS) based on diffusion-weighted imaging (DWI) of brain magnetic resonance imaging. Neurological impairment was assessed by the National Institute of Health Stroke Scale (NIHSS). The association of serum C1q levels with DMTS or NIHSS was investigated by Pearson's or Spearman's correlation analysis.ResultsSerum C1q levels of patients with AIS were significantly higher than those of individuals without AIS. Serum levels of C1q were associated with DMTS (r=0.511, p<0.001) and NIHSS (r=0.433, p<0.001) among patients with AIS.ConclusionSerum C1q concentration was positively associated with DMTS and NIHSS of patients with AIS.Copyright © 2020 Elsevier Inc. All rights reserved.

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