• AJNR Am J Neuroradiol · Oct 2003

    Case Reports

    Neurotoxicity of intrathecal methotrexate: MR imaging findings.

    • Claudio Sandoval, Martin Kutscher, Somasundaram Jayabose, and Michael Tenner.
    • Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA.
    • AJNR Am J Neuroradiol. 2003 Oct 1; 24 (9): 1887-90.

    AbstractWe report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia. Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion recovery imaging findings were normal at presentation. Three weeks later, diffusion abnormalities resolved, and T2-weighted studies showed increased signal intensity of prolonged T2 changes in areas of prior restricted diffusion. We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.

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