• Charlene M Rapsey, Carmen C W Lim, Ali Al-Hamzawi, Jordi Alonso, Ronny Bruffaerts, J M Caldas-de-Almeida, Silvia Florescu, Giovanni de Girolamo, Chiyi Hu, Ronald C Kessler, Viviane Kovess-Masfety, Daphna Levinson, María Elena Medina-Mora, Sam Murphy, Yutaka Ono, Maria Piazza, Jose Posada-Villa, Margreet ten Have, Bogdan Wojtyniak, and Kate M Scott.
• Department of Psychological Medicine, University of Otago, Dunedin, New Zealand. Electronic address: charlene.rapsey@otago.ac.nz.
• J Psychosom Res. 2015 Nov 1; 79 (5): 333-9.

ObjectivesCOPD and mental disorder comorbidity is commonly reported, although findings are limited by substantive weaknesses. Moreover, few studies investigate mental disorder as a risk for COPD onset. This research aims to investigate associations between current (12-month) DSM-IV mental disorders and COPD, associations between temporally prior mental disorders and subsequent COPD diagnosis, and cumulative effect of multiple mental disorders.MethodsData were collected using population surveys of 19 countries (n=52,095). COPD diagnosis was assessed by self-report of physician's diagnosis. The World Mental Health-Composite International Diagnostic Interview (WMH-CIDI) was used to retrospectively assess lifetime prevalence and age at onset of 16 DSM-IV disorders. Adjusting for age, gender, smoking, education, and country, survival analysis estimated associations between first onset of mental disorder and subsequent COPD diagnosis.ResultsCOPD and several mental disorders were concurrently associated across the 12-month period (ORs 1.5-3.8). When examining associations between temporally prior disorders and COPD, all but two mental disorders were associated with COPD diagnosis (ORs 1.7-3.5). After comorbidity adjustment, depression, generalized anxiety disorder, and alcohol abuse were significantly associated with COPD (ORs 1.6-1.8). There was a substantive cumulative risk of COPD diagnosis following multiple mental disorders experienced over the lifetime.ConclusionsMental disorder prevalence is higher in those with COPD than those without COPD. Over time, mental disorders are associated with subsequent diagnosis of COPD; further, the risk is cumulative for multiple diagnoses. Attention should be given to the role of mental disorders in the pathogenesis of COPD using prospective study designs.Copyright © 2015 Elsevier Inc. All rights reserved.

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