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- Ayami Nonomura, Akihiro Tamori, Hoang Hai, Ritsuzo Kozuka, Hideki Fujii, Sawako Uchida-Kobayashi, Masaru Enomoto, and Norifumi Kawada.
- Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan.
- Intern. Med. 2021 Nov 1; 60 (21): 344134453441-3445.
AbstractGlecaprevir/pibrentasvir (GLE/PIB) is a pan-genotype anti-hepatitis C virus (HCV) therapy with high efficacy and safety. However, evidence supporting retreatment following failure of the GLE/PIB regimen is limited. We herein report 3 non-cirrhotic cases involving two men aged 51 and 58 years old and a woman aged 68 years old infected with HCV genotype 1a, 2a, and 3b respectively who failed anti-HCV therapies including GLE/PIB therapy. With combination therapy of sofosbuvir/velpatasvir plus ribavirin (SOF/VEL+RBV) for 24 weeks, all 3 patients had achieved a sustained viral response (SVR) at 24 weeks after completing treatment. SOF/VEL+RBV therapy was effective for retreatment of HCV after failure of GLE/PIB therapy.
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