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- Naokata Kutsuzawa, Takahisa Takihara, Yoshiki Shiraishi, Hiroshi Kajiwara, Tadashi Imanishi, Yuma Fukutomi, Katsuhiko Kamei, Mari Takahashi, Keito Enokida, Yukihiro Horio, Yoko Ito, Naoki Hayama, Tsuyoshi Oguma, and Koichiro Asano.
- Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
- Intern. Med. 2021 Nov 15; 60 (22): 3581-3584.
AbstractHypersensitivity pneumonitis (HP) sometimes develops in people working in specific environments. We herein report a case of occupation-related HP in a citrus farmer in Japan. A 66-year-old man developed a fever, dyspnea, and general malaise in March after working near a trash dump filled with moldy tangerines. He presented with leukocytosis, bilateral lung opacities on chest radiographs, and intra-alveolar and interstitial lymphocytic inflammation with fibrotic change on a lung biopsy. His symptoms disappeared after admission and recurred on a revisit to the workplace. Fungal culture and a mycobiome analysis using next-generation sequencing suggested an association with exposure to Penicillium digitatum.
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