• Pediatr. Nephrol. · Jun 2017

    Review

    Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology.

    • Samriti Dogra and Frederick Kaskel.
    • Division of Pediatric Nephrology, Department of Pediatrics, Connecticut Children's Medical Center, 282 Washington Street, Hartford, CT, 06095, USA. sdogra@connecticutchildrens.org.
    • Pediatr. Nephrol. 2017 Jun 1; 32 (6): 965-974.

    AbstractSteroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the newer advances in understanding the molecular etiologies for a variety of podocyte abnormalities, potential circulating factors that may initiate and sustain the steroid-resistant state, genetic mutations, and precision medicine treatment modalities in this continuously perplexing disorder.

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