• Alex D Wright, Margaret F Beazley, Arthur R Bradwell, Ian M Chesner, Richard N Clayton, Peter J G Forster, Peter Hillenbrand, Christopher H E Imray, and Birmingham Medical Research Expeditionary Society.
• Department of Medicine, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
• Wilderness Environ Med. 2004 Jan 1; 15 (1): 25-31.

ObjectiveTo study the effect of medroxyprogesterone on blood gases and cerebral regional oxygenation at high altitude, alone and in conjunction with acetazolamide, and to assess the effect on acute mountain sickness (AMS).DesignTwo placebo-controlled trials during rapid ascent to high altitude.ParticipantsIn the first trial, 20 participants, and in the second trial, 24 participants.SettingDuring rapid ascent to 4680 m and on rapid ascent to 5200 m.InterventionIn the first trial, participants were randomized to receive medroxyprogesterone 30 mg or a placebo twice a day. In the second trial, participants were randomly assigned to one of 4 groups: a placebo twice daily, medroxyprogesterone 30 mg twice daily, acetazolamide 250 mg plus a placebo twice daily, or acetazolamide 250 mg plus medroxyprogesterone 30 mg twice daily.Main Outcome MeasuresBlood gas changes and symptom scores of AMS in both trials and cerebral regional oxygen saturations in the first trial only.ResultsMedroxyprogesterone improved peripheral oxygen saturations in both trials and improved PaO2 in combination with acetazolamide. Cerebral regional oxygen saturation was not altered by medroxyprogesterone. The reduction in symptom scores and in the extent of AMS was not significant in this limited study.ConclusionsMedroxyprogesterone acts as a respiratory stimulant, but the clinical benefit regarding the development of AMS was unproven at high altitude. Combined medroxyprogesterone and acetazolamide gave the best PaO2.

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