• Emmanuel Lansac, Olivier Bouchot, Eric Arnaud Crozat, Rachid Hacini, Fabien Doguet, Roland Demaria, Alain Leguerrier, Jerome Jouan, Didier Chatel, Stephane Lopez, Thierry Folliguet, Christophe Acar, Pascal Leprince, Thierry Langanay, Oliver Jegaden, Jean Paul Bessou, Bernard Albat, Christian Latremouille, Jean-Noel Fabiani, Georges Fayad, Jean Pierre Fleury, Blandine Pasquet, Mathieu Debauchez, Isabelle Di Centa, and Florence Tubach.
• Department of Cardiac Surgery, Institut Mutualiste Montsouris, Paris, France. Electronic address: emmanuel.lansac@imm.fr.
• J. Thorac. Cardiovasc. Surg. 2015 Feb 1; 149 (2 Suppl): S37-45.

ObjectiveThe study objective was to compare the 30-day outcomes of a standardized aortic valve repair technique (REPAIR group) associating root remodeling with an expansible aortic ring annuloplasty versus mechanical composite valve and graft (CVG group) replacement in treating aortic root aneurysms.MethodsA total of 261 consecutive patients with aortic root aneurysm were enrolled in this multicentric prospective cohort (131 in the CVG group, 130 in the REPAIR group) in 20 centers. The main end point is a composite criterion including mortality; reoperation; thromboembolic, hemorrhagic, or infectious events; and heart failure. Secondary end points were major adverse valve-related events. Crude and propensity score adjusted estimates are provided.ResultsThe mean age was 56.1 years, and the valve was bicuspid in 115 patients (44.7%). The median (interquartile range) preoperative aortic insufficiency grade was 2.0 (1.0-3.0) in the REPAIR group and 3.0 (2.0-3.0) in the CVG group (P = .0002). Thirty-day mortality was 3.8% (n = 5) in both groups (P = 1.00). Despite a learning curve and longer crossclamp times for valve repair (147.7 vs 99.8 minutes, P < .0001), the 2 groups did not differ significantly for the main criterion (odds ratio, 1.31; 95% confidence interval, 0.72-2.40; P = .38) or 30-day mortality (odds ratio, 0.99; 95% confidence interval, 0.28-3053; P = .99), with a trend toward more frequent major adverse valve-related events in the CVG group (odds ratio, 2.52; 95% confidence interval, 0.86-7.40; P = .09). At discharge, 121 patients (96.8%) in the REPAIR group had grade 0 or 1 aortic insufficiency.ConclusionsA new standardized approach to valve repair, combining an expansible aortic annuloplasty ring with the remodeling technique, presented similar 30-day results to mechanical CVG with a trend toward reducing major adverse valve-related events. Analysis of late outcomes is in process for 3- and 10-year follow-ups.Copyright © 2015. Published by Elsevier Inc.

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