• Pedro Zapater, Lucia Llanos, Claudia Barquero, Pablo Bellot, Sonia Pascual, Fernando Carnicer, Jose Maria Palazón, Paula Gimenez, Angel Esteban, Lourdes Llorca, Ruben Francés, Jose Francisco Horga, and Jose Such.
• CIBERehd, Institute of Health Carlos III, Madrid, Spain; Unit of Clinical Pharmacology, University General Hospital, Alicante, Spain; Institute of Bioengineering, University Miguel Hernandez, Alicante, Spain.
• Basic Clin. Pharmacol. Toxicol. 2015 Mar 1; 116 (3): 257-63.

AbstractUse of non-steroidal anti-inflammatory drugs in cirrhosis has been associated with impairment of renal function based on its ability to inhibit the renal production of prostaglandins. Renal effects of dipyrone in patients with cirrhosis have not been evaluated. We aimed to assess the renal effect of therapeutic doses of dipyrone used for short periods of time in patients with cirrhosis. Twenty-nine patients with cirrhosis were included in an observer-blind clinical trial. Patients were randomized to receive three times a day oral acetaminophen (500 mg; N = 15) or dipyrone (575 mg; N = 14) for 72 hr. Serum and urine samples were obtained at baseline, 48 and 72 hr, and cystatin C, creatinine, aldosterone, 6-keto-Prostaglandin-F1 alpha and prostaglandin E2 were measured. Cystatin C and creatinine levels remained comparable in patients treated with acetaminophen and dipyrone. Urine and serum prostaglandins concentrations were significantly decreased at 72 hr in patients treated with dipyrone regardless of the status of ascites. One patient with ascites treated with dipyrone required a paracentesis and developed renal insufficiency. We conclude that dipyrone and acetaminophen did not reduce renal function when used for short periods of time (up to 72 hr) in patients with cirrhosis. However, considering that dipyrone lowered renal vasodilator prostaglandins synthesis, acetaminophen appears as the safest choice with respect to kidney function in cirrhosis.© 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

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