• Shahirose Premji, Tanis Fenton, and Reg Sauve.
• Faculty of Nursing and Paediatrics and Community Health Sciences, University of Calgary, Calgary, and the Alberta Children's Hospital, Canada. premjis@ucalgary.ca
• Jpen Parenter Enter. 2006 Nov 1; 30 (6): 507-14.

BackgroundHigh protein intake may be associated with negative consequences such as acidosis, uremia, and elevated levels of circulating amino acids (eg, phenylalanine levels). We performed a systematic review of randomized controlled trials to determine whether formula-fed low-birthweight infants could tolerate protein intakes>or=3.0 g/kg/d in their initial hospital stay, without adverse consequences.MethodsRandomized controlled trials contrasting levels of protein intakes as low (<3.0 g/kg/d), high (>or=3.0 g/kg/d but <4.0 g/kg/d), or very high protein intake (>or=4.0 g/kg/d) while other nutrients were held constant, were identified through a systematic search of the literature. Standard methods of the Cochrane Collaboration were used by 2 independent reviewers, with the third reviewer facilitating consensus decision making.ResultsA meta-analysis of 5 randomized trials indicated improved weight gain (weighted mean difference [WMD] 2.36 g/kg/d; 95% confidence interval [CI] 1.31-3.40) and higher nitrogen accretion (WMD 143.7 mg/kg/d; 95% CI 128.7-158.8) with high (>or=3.0 g/kg/d but <4.0 g/kg/d) compared with low (<3.0 g/kg/d) protein intakes while other nutrients were kept constant. No data were available for IQ or Bayley scores at 18 months or later or for very high protein intakes (>or=4.0 g/kg/d). No significant differences were seen in rates of necrotizing enterocolitis, sepsis, or diarrhea.ConclusionsAccelerated weight and nitrogen accretion were noted with higher protein intakes in "healthy" formula-fed low-birthweight infants. This benefit could not be weighed against the adverse consequences of elevated blood urea nitrogen levels and increased metabolic acidosis and neurodevelopmental abnormalities.

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