• Ann. Thorac. Surg. · May 2001

    Multicenter Study

    Fifteen-year experience with the mitral Carpentier-Edwards PERIMOUNT pericardial bioprosthesis.

    • M A Marchand, M R Aupart, R Norton, I R Goldsmith, L C Pelletier, M Pellerin, T Dubiel, W J Daenen, P Herijgers, F P Casselman, M P Holden, and T E David.
    • Department of Cardiothoracic Surgery and Cardiology, Hĵpital Trousseau and Francois Rabelais University, Tours, France. marchand@med.univ-tours.fr
    • Ann. Thorac. Surg. 2001 May 1; 71 (5 Suppl): S236-9.

    BackgroundThis multicenter study concerning the mitral PERIMOUNT valve previously reported clinical results at 12 years; this report updates the performance to 15 years postoperatively.MethodsThe 435 patients (mean age 60.7+/-11.6 years; 41.1% male) underwent implantation with the PERIMOUNT valve between 1984 and 1989 at seven institutions. Follow-up was complete for 96.1% of the cohort. The mean follow-up was 8.1+/-4.4 years (range 0 to 15.4 years) for a total of 3492 patient-years.ResultsThere were 34 (7.8%) operative deaths, one (0.2%) valve related. The late mortality rate was 5.3%/patient-year (2.2%/patient-year valve related). At 14 years, the overall actuarial survival rate was 37.1%+/-3.3% (63.1%+/-4.4% valve related). Actuarial freedom from complications at 14 years was as follows: thromboembolism, 83.8%+/-3.2% (1.1%/patient-year); hemorrhage, 86.6%+/-3.2% (1.1%/patient-year); and explant due to structural valve deterioration (SVD), 68.8%+/-4.7%. Actual freedom from explant due to SVD was 83.4%+/-2.3%. Rates of structural failure decreased with increasing age at implant.ConclusionsThe Carpentier-Edwards PERIMOUNT Pericardial Bioprosthesis is a reliable choice for a tissue valve in the mitral position, especially in patients more than 60 years of age.

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