• Marzieh Mortezanejad, Fatemeh Ehsani, Nooshin Masoudian, Maryam Zoghi, and Shapour Jaberzadeh.
• Neuromuscular Rehabilitation Research Centre, Semnan University of Medical Sciences, Semnan, Iran.
• Clin Rehabil. 2020 Aug 1; 34 (8): 1103-1111.

ObjectiveTo compare the effects of anodal trans-cranial direct current stimulation (a-tDCS) over primary motor and dorsolateral prefrontal cortices on Fatigue Severity Scale and its lasting effect on fatigue reduction and improvement in quality of life in patients with multiple sclerosis.DesignA randomized, double-blinded, sham-controlled parallel clinical trial study.SettingNeurological physiotherapy clinics.SubjectsThirty-nine participants were randomly assigned to three groups: dorsolateral prefrontal cortex a-tDCS, primary motor a-tDCS (experimental groups) and sham a-tDCS. Finally, 36 participants completed the whole study (n = 12 in each group).InterventionsParticipants in the experimental groups received six-session a-tDCS (1.5 mA, 20 minutes) during two weeks (three sessions per week). The sham group received six sessions of 20-minute sham stimulation.Main MeasuresThe Fatigue Severity Scale and quality of life were assessed before, immediately and four weeks after the intervention.ResultsFindings indicated a significant reduction in the Fatigue Severity Scale and a significant increase in the quality of life in both experimental groups, immediately after the intervention (P < 0.001), while Fatigue Severity Scale and quality of life changes were not significant in the sham a-tDCS group (P > 0.05). In addition, improvement of the variables remained four weeks after the intervention in dorsolateral prefrontal cortex a-tDCS (mean differences (95% confidence interval): 0.03 (-0.63 to 0.68) as compared to primary motor (-0.62 (-0.11 to -1.14) and sham a-tDCS groups (-0.47 (-1.37 to 0.43)).ConclusionBoth primary motor and dorsolateral prefrontal cortex a-tDCS as compared to sham intervention can immediately improve fatigue and quality of life. However, the effects last up to four weeks only by the dorsolateral prefrontal cortex a-tDCS.

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