• Eur. J. Clin. Pharmacol. · Oct 2020

    Calling for an exponential escalation scheme in vaccine development for COVID-19.

    • Martin Wehling.
    • Institute of Clinical Pharmacology Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. martin.wehling@medma.uni-heidelberg.de.
    • Eur. J. Clin. Pharmacol. 2020 Oct 1; 76 (10): 1471-1472.

    PurposeCOVID-19 as a pandemic calls for rapid development of vaccines.MethodsHere a proposal of a seamless, adaptive, phase 1-3 trial for accelerated vaccine development is described.ResultsStarting at 10, the number of vaccinated volunteers would exponentially increase by tenfold at an interval of 2 weeks; close surveillance of antibody responses, safety and efficacy is necessary. After only 16 weeks, general vaccination would be feasible if supply meets the demand.ConclusionA COVID-19 vaccine would be rapidly available at a slightly increased risk for undetected late side effects or insufficient efficacy if compared with standard vaccine development schemes.

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