• Future oncology · Feb 2018

    Review

    Denosumab for the treatment of bone disease in solid tumors and multiple myeloma.

    • Andrew J Yee and Noopur S Raje.
    • Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
    • Future Oncol. 2018 Feb 1; 14 (3): 195-203.

    AbstractBone is a common site for malignant involvement, either as a site of metastasis, especially in breast or prostate cancer, or as a defining characteristic of the disease, as in multiple myeloma. Bone disease is a major source of morbidity, and half of patients with bone involvement develop skeletal-related events such as pathological fractures or cord compression requiring surgery and/or radiation. Skeletal involvement also increases mortality, as pathologic fractures increase the risk of dying by 20-40%. Osteoclast inhibition with bisphosphonates such as zoledronic acid and recently denosumab has been a significant improvement for bone disease. This review will focus on denosumab in the treatment of bone metastases and highlight the recent findings in multiple myeloma.

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