Hantavirus and acute appendicitis--the diagnosis behind the

J. Clin. Virol. · Feb 2012

Case Reports

Hantavirus and acute appendicitis--the diagnosis behind the diagnosis?

A 33-year-old man with a history of acute lower abdominal pain was admitted to the emergency room. After laparoscopic appendectomy and pathological confirmed acute appendicitis the patient developed thrombocytopenia and acute renal failure. Serological testing for hantaviruses revealed a positive result for PUUV IgG and IgM. ⋯ The high percentage of patients with hantavirus infection and severe abdominal pain is remarkable and, up to now, unexplained. To our knowledge this is the first report demonstrating PUUV antigen in the human intestine. Further studies are warranted whether hantaviruses are setting the stage for a secondary bacterial infection or cause an inflammation itself.

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- Joerg Latus, Matthias Fritzenkötter, Jonas Schmidt-Chanasit, Klara Tenner-Racz, Tobias Leibold, Martin Kimmel, German Ott, Evelyn Ting, Mark Dominik Alscher, and Niko Braun.
- Department of Internal Medicine, Division of Nephrology, Robert-Bosch Hospital, Auerbachstr. 110, 70376 Stuttgart, Germany. Joerg.latus@rbk.de
- J. Clin. Virol. 2012 Feb 1; 53 (2): 156-8.
AbstractA 33-year-old man with a history of acute lower abdominal pain was admitted to the emergency room. After laparoscopic appendectomy and pathological confirmed acute appendicitis the patient developed thrombocytopenia and acute renal failure. Serological testing for hantaviruses revealed a positive result for PUUV IgG and IgM. Immunohistochemical work-up detected PUUV antigen in endothelial cells of capillaries and larger vessels. The high percentage of patients with hantavirus infection and severe abdominal pain is remarkable and, up to now, unexplained. To our knowledge this is the first report demonstrating PUUV antigen in the human intestine. Further studies are warranted whether hantaviruses are setting the stage for a secondary bacterial infection or cause an inflammation itself.Copyright © 2011 Elsevier B.V. All rights reserved.

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Hantavirus and acute appendicitis--the diagnosis behind the diagnosis?

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