• Am J Ther · Sep 2016

    Case Reports

    Mycobacterium Avium Complex Septic Arthritis in a Patient Treated by Infliximab.

    • Nathalie Chalhoub, Claudiu Georgescu, and Nezam Altorok.
    • 1Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH; 2Division of Infectious Diseases, Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH; and 3Division of Rheumatology and Immunology, Department of Internal Medicine, University of Toledo Medical Center, Toledo, OH.
    • Am J Ther. 2016 Sep 1; 23 (5): e1222-5.

    AbstractInfliximab is one of the TNF-α inhibitors, a class of medications that made a revolution in treatment of rheumatic diseases especially rheumatoid arthritis. The activation of tuberculosis and atypical mycobacterial infections has been described in the setting of TNF-α inhibitor therapy, but septic arthritis relating to this treatment has not yet been reported in previous literature. We describe a 50-year-old woman with dermatomyositis who developed Mycobacterium Avium Complex septic arthritis, while being treated with infliximab for active skin disease. This case highlights an important complication related to therapy with TNF-α inhibitors.

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