• Clinics in chest medicine · Mar 2020

    Review

    Biomarkers in Lung Cancer.

    • Catherine R Sears and Peter J Mazzone.
    • Department of Medicine, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, 980 West Walnut Street, Room R3-C400, Indianapolis, IN, USA. Electronic address: crufatto@iu.edu.
    • Clin. Chest Med. 2020 Mar 1; 41 (1): 115-127.

    AbstractBiomarkers that focus on lung cancer risk assessment, detection, prognosis, diagnosis, and personalized treatment are in various stages of development. This article provides an overview of lung cancer biomarker development, focusing on clinical utility and highlighting 2 unmet clinical needs: selection of high-risk patients for lung cancer screening and differentiation of early lung cancer from benign pulmonary nodules. The authors highlight biomarkers under development and those lung cancer screening and nodule management biomarkers post-clinical validation. Finally, trends in lung cancer biomarker development that may improve accuracy and accelerate implementation in practice are discussed.Copyright © 2019 Elsevier Inc. All rights reserved.

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