• Amir H Faraji, Sibi Rajendran, Andrea S Jaquins-Gerstl, Hunter J Hayes, and R Mark Richardson.
• Department of Neurological Surgery, Houston Methodist Hospital, Houston, Texas, USA; Center for Neuroregeneration, Houston Methodist Research Institute, Houston, Texas, USA; Center for Translational Neural Prosthetics and Interfaces, Houston Methodist Research Institute, Houston, Texas, USA. Electronic address: ahfaraji@houstonmethodist.org.
• World Neurosurg. 2021 Jul 1; 151: 163-171.

AbstractStereotactic neurosurgery involves a targeted intervention based on congruence of image guidance to a reference fiducial system. This discipline has widespread applications in radiosurgery, tumor therapy, drug delivery, functional lesioning, and neuromodulation. In this article, we focused on convection-enhanced delivery to deliver therapeutic agents to the brain addressing areas of research and clinical development. We performed a robust literature review of all relevant articles highlighting current efforts and challenges of making this delivery technique more widely understood. We further described key biophysical properties of molecular transport in the extracellular space that may impact the efficacy and control of drug delivery using stereotactic methods. Understanding these principles is critical for further refinement of predictive models that can inform advances in stereotactic techniques for convection-enhanced delivery of therapeutic agents to the brain.Copyright © 2021 Elsevier Inc. All rights reserved.

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