• Crit Care · May 2021

    Tailored modulation of the inflammatory balance in COVID-19 patients admitted to the ICU?-a viewpoint.

    • Marnix Kuindersma, Rocio Ramos Diaz, and Peter E Spronk.
    • Department of Intensive Care Medicine, Gelre Hospitals, Albert Schweiterlaan 31, Apeldoorn, The Netherlands. m.kuindersma@gelre.nl.
    • Crit Care. 2021 May 25; 25 (1): 178.

    AbstractA growing consensus seems to be emerging that dexamethasone is a crucial component in the treatment of COVID-19-associated oxygen-dependent respiratory failure. Although dexamethasone has an undeniably beneficial effect on the inflammatory response in a subgroup of patients, the potential negative effects of corticosteroids must also be considered. In view of these negative effects, we argue that a one-size-fits-all dexamethasone approach may be potentially harmful in specific subsets of patients with COVID-19-associated ARDS. We propose a different individually tailored treatment strategy based on the patient's inflammatory response.

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