• Thanachai Panaput, Sadudee Peerapornratana, Phatadon Sirivongrangson, Win Kulvichit, Nuttha Lumlertgul, Jonny Jonny, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong, and Nattachai Srisawat.
• Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand.
• J Crit Care. 2021 Oct 1; 65: 18-25.

PurposeTo determine the effects of modalities of renal replacement therapy (RRT) on the 30-d mortality and renal recovery in patients with acute kidney injury (AKI).Materials And MethodsA multicenter cohort study was conducted in 17 hospitals from Thailand and Indonesia. We recruited patients who were admitted to the Intensive care unit and diagnosed with AKI. Relevant mode of RRT, as intermittent hemodialysis (IHD), continuous renal replacement therapy (CRRT), peritoneal dialysis (PD), or sustained low efficiency dialysis (SLED), was initiated as indicated.ResultsFrom 2844 patients with AKI, 449 cases (8.1%) received RRT. There were no significant differences in the 30-d mortality between those initially treated with CRRT, PD, and SLED compared to those treated with IHD. The renal recovery was similar for each RRT mode. The three independent factors of death were the primary diagnosis of kidney disease, higher APACHE II score, and non-renal SOFA score. Only 48 (10.7%) patients had been switched to another mode of RRT.ConclusionsAll four modes of RRT (IHD, CRRT, PD, and SLED) are acceptable treatments for severe AKI and gave a similar survival rate.Copyright © 2021 Elsevier Inc. All rights reserved.

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