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The Journal of pediatrics · Aug 1997
Clinical TrialTreatment of visceral leishmaniasis in children with liposomal amphotericin B.
- L di Martino, R N Davidson, R Giacchino, S Scotti, F Raimondi, E Castagnola, L Tasso, A Cascio, L Gradoni, M Gramiccia, M Pettoello-Mantovani, and A D Bryceson.
- Department of Pediatrics, Institute Giannina Gashni, Genoa, Italy.
- J. Pediatr. 1997 Aug 1; 131 (2): 271-7.
AbstractWe used liposomal amphotericin B as first-choice treatment of visceral leishmaniasis in 106 immunocompetent children who acquired the infection in a temperate region of southern Europe (Italy) where Leishmania infantum visceral leishmaniasis is endemic. The aim of the study was to identify the minimum total dose of liposomal amphotericin B needed to cure the infection in children and reduce the period of hospitalization. We conclude that the optimal regimen in immunocompetent children with L. infantum visceral leishmaniasis to be a total dose of 18 mg/kg of liposomal amphotericin B (3 mg/kg per day for 5 days, followed by 3 mg/kg administered as an outpatient regimen on day 10).
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