• Mario Weitz, Corinna Kiessling, Markus Friedrich, Susanna Prösch, Conny Höflich, Florian Kern, Hans-Dieter Volk, Wolfram Sterry, Khusru Asadullah, and Wolf-Dietrich Döcke.
• Institute of Medical Immunology, University Hospital Charité, Berlin Humboldt University, Berlin, Germany.
• Exp. Dermatol. 2011 Jul 1; 20 (7): 561-7.

BackgroundPreviously, we have reported a frequent association of active plaque psoriasis with inflammation-mediated cytomegalovirus (CMV) reactivation.ObjectivesThis study aimed at characterizing the impact of CMV infection on psoriasis disease activity and peripheral cellular adaptive immune response.Patients/MethodsTwenty nine patients with active plaque psoriasis and 29 healthy controls were analysed for CMV-serostatus, CMV-antigenaemia, frequencies of peripheral CMV-specific T cells and the immunophenotype of peripheral CD8+ T cells.Results(i) Psoriasis severity was higher in CMV-seropositive patients and positively correlated to the severity of CMV-antigenaemia. (ii) In comparison to CMV-seropositive healthy controls, CMV-seropositive psoriasis patients showed a reduced frequency of circulating CMV-specific T cells that increased under effective antipsoriatic therapy. (iii) The immunophenotype of peripheral CD8+ T cells was dominated by CMV-seroprevalence. (iv) Selective analysis of CMV-seronegative psoriasis patients revealed a strong expansion of a - probably early activated - CD8+ T-cell population with the yet undescribed differentiation phenotype 'CD45RA-dim/CD11a-dim'. Under effective antipsoriatic therapy this population decreased in parallel to an increase of effector differentiated CD8+ T cells.ConclusionsTaken together with our previous results of inflammation-mediated CMV reactivation in psoriasis, our data support the concept of an interactive relationship between psoriasis and CMV infection which may be mediated by peripheral CD8+ T cells.© 2011 John Wiley & Sons A/S.

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