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Case Reports
Efficacy of 4-methylpyrazole in ethylene glycol poisoning: clinical and toxicokinetic aspects.
- P Harry, A Turcant, G Bouachour, P Houze, P Alquier, and P Allain.
- Centre Anti-Poisons-Réanimation Médicale, CHU, Angers, France.
- Hum Exp Toxicol. 1994 Jan 1; 13 (1): 61-4.
AbstractPotentially fatal ethylene glycol intoxication in an adult with normal renal function was treated with 4-methylpyrazole administered three hours after the incident occurred. The plasma ethylene glycol concentration was 3.5 g l-1 on admission. The metabolic acidosis present on admission resolved within four hours, and the subsequent clinical course was uneventful. The apparent plasma half-life of ethylene glycol was 16 h and the mean renal and plasma clearances of ethylene glycol were 24 and 25 ml min-1, respectively. These results support the hypothesis that complete blockade of hepatic metabolism of ethylene glycol is achieved by 4-methylpyrazole. The only side-effect observed as a result of treatment was a transient slight increase in serum transaminase activity.
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