• Zhongguo Yi Xue Ke Xue Yuan Xue Bao · Dec 2000

    Randomized Controlled Trial Clinical Trial

    [Prevention and release of epidural-morphine-induced urinary retention with phenoxybenzamine and neostigmine].

    • J Tang, Q Xu, and T Ye.
    • Department of Anesthesiology, the 4th Hospital of Zhenjiang, Zhenjiang 212001, China. tpopo@yeah.net
    • Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Dec 1; 22 (6): 595-6.

    ObjectiveTo study the effects of preoperative phenoxybenzamine (o.p) on preventing epidural-morphine-induced urinary retention and effects of neostigmine on releasing it.Methods80 patients who received epidural morphine to release postoperative pain were divided into 4 groups randomly and received preoperative phenoxybenzamine (group P, n = 20), neostigmine (i. m) when urinary retention happened (group N, n = 20), both drugs (group U, n = 20), and without drugs (Control, n = 20), respectively. The incidences of urinary retention and release were observed.ResultsNo significant decrease (P > 0.05) happened after operation in the incidence of epidural-morphine-induced urinary retention both in the group P and in the group N. Neostigmine(i. m) could significantly release (P < 0.001) the epidural-morphine-induced urinary retention when phenoxybenzamine was administrated preoperatively.ConclusionPreoperative phenoxybenzamine can not prevent epidural-morphine-induced urinary retention. Neostigmine can release the urinary retention only when preoperative phenoxybenzamine is used.

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