• Alberto Palazzuoli, Franco Ruberto, Gaetano M De Ferrari, Giovanni Forleo, Gioel G Secco, Gaetano M Ruocco, Fabrizio D'Ascenzo, Francesco Mojoli, Silvia Monticone, Anita Paggi, Marco Vicenzi, Silvia Corcione, Anna G Palazzo, Maurizio Landolina, Erika Taravelli, Guido Tavazzi, Francesco Blasi, Massimo Mancone, Lucia I Birtolo, Francesco Alessandri, Fabio Infusino, Francesco Pugliese, Francesco Fedele, Francesco Giuseppe De Rosa, Michael Emmett, Jeffrey M Schussler, Peter A McCullough, and Kristen M Tecson.
• Cardiovascular Diseases Unit, Department of Medical Sciences, AOUS Le Scotte Hospital, University of Siena, Siena, Italy.
• Crit Care Explor. 2020 Sep 1; 2 (9): e0220.

ObjectivesTo describe patients according to the maximum degree of respiratory support received and report their inpatient mortality due to coronavirus disease 2019.DesignAnalysis of patients in the Coracle registry from February 22, 2020, to April 1, 2020.SettingHospitals in the Piedmont, Lombardy, Tuscany, and Lazio regions of Italy.PatientsNine-hundred forty-eight patients hospitalized for coronavirus disease 2019.InterventionsNone.Measurements And Main ResultsAmong 948 patients, 122 (12.87%) received invasive ventilation, 637 (67.19%) received supplemental oxygen only, and 189 (19.94%) received no respiratory support. The median (quartile 1-quartile 3) age was 65 years (54-76.59 yr), and there was evidence of differential respiratory treatment by decade of life (p = 0.0046); patients greater than 80 years old were generally not intubated. There were 606 men (63.9%) in this study, and they were more likely to receive respiratory support than women (p < 0.0001). The rate of in-hospital death for invasive ventilation recipients was 22.95%, 12.87% for supplemental oxygen recipients, and 7.41% for those who received neither (p = 0.0004). A sensitivity analysis of the 770 patients less than 80 years old revealed a lower, but similar mortality trend (18.02%, 8.10%, 5.23%; p = 0.0008) among the 14.42%, 65.71%, and 19.87% of patients treated with mechanical ventilation, supplemental oxygen only, or neither. Overall, invasive ventilation recipients who died were significantly older than those who survived (median age: 68.5 yr [60-81.36 yr] vs 62.5 yr [55.52-71 yr]; p = 0.0145).ConclusionsAmong patients hospitalized for coronavirus disease 2019, 13% received mechanical ventilation, which was associated with a mortality rate of 23%.Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

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