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Comparative Study
Medial temporal atrophy as a magnetic resonance imaging marker for Alzheimer's disease.
- L L Barclay, C Linden, and R Murtagh.
- Department of Neurology, University of South Florida Health Sciences Center, Tampa 33612.
- J Neuroimaging. 1992 Jul 1; 2 (3): 131-5.
AbstractMedial temporal lobe atrophy (MTLA) on brain magnetic resonance imaging (MRI) may help differentiate Alzheimer's disease (AD) from multiinfarct dementia (MID) and other dementias. MTLA was seen in 6 of 11 patients with clinically diagnosed AD, 16 of 20 with mixed dementia (with both AD and MID), 1 of 5 with psychiatric disease, and in none of 32 with MID or 8 with other dementias (p less than 0.0001). Increased patchy periventricular signal, or "unidentified bright objects" were seen in 2 of 11 patients with AD, 10 of 20 patients with AD and MID, and 26 of 32 patients with MID. A larger series with autopsy correlation may verify that MTLA is a reasonably specific marker for AD, and unidentified bright objects are a sensitive, but not specific, marker for vascular dementias.
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