• Jean-François Sarrazin, Michael Kuehne, Darryl Wells, Nagib Chalfoun, Thomas Crawford, Warangkna Boonyapisit, Eric Good, Aman Chugh, Hakan Oral, Krit Jongnarangsin, Frank Pelosi, Fred Morady, and Frank Bogun.
• Department of Cardiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
• Heart Rhythm. 2008 Dec 1; 5 (12): 1709-14.

BackgroundPace mapping is used to identify critical areas for postinfarction ventricular tachycardia (VT). Unexcitable scar during pacing with standard output can identify borders of the reentry circuit. Unexcitable scar is not thought to contain surviving muscle fibers critical to the circuit. Due to current-to-load mismatch or a deep seated isthmus, higher power might be required in order to obtain capture.ObjectiveThe purpose of this study was to evaluate the value of high-output pacing in patients with postinfarction VT.MethodsIn a consecutive series of 18 patients (15 men, age 62 +/- 9, EF 0.29 +/- 0.15) with postinfarction VT, a voltage map was obtained and bipolar pace mapping was performed in areas with low voltage (<1.5 mV) at an output of 10 mA and 2 ms pulse width (PW). High-output capture was defined as capture that failed at these settings but succeeded at higher pacing output. The pacing output was increased to 20 mA at 2 ms, and the PW was increased to 10 ms as required to achieve capture.ResultsSeventy-seven VTs were induced. Thirty-nine isthmus sites were identified. Focal areas with high-output capture were observed in 12/18 patients (output: 20 mA; mean PW: 7.3 +/- 3.5 ms). In 9/18 patients, this area was critical for the reentry circuit of 10 clinical VTs (23% of isthmus sites). In one third of patients, isthmus sites were identified only by high-output pacing.ConclusionHigh-output pacing can be helpful in identifying critical areas of postinfarction VT that otherwise may be missed.

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