• J. Am. Coll. Surg. · Jan 2014

    Randomized Controlled Trial

    Early angiopoietin-2 levels after onset predict the advent of severe pancreatitis, multiple organ failure, and infectious complications in patients with acute pancreatitis.

    • Karel T Buddingh, Lyan G Koudstaal, Hjalmar C van Santvoort, Marc G Besselink, Robin Timmer, Camiel Rosman, Harry van Goor, Rian M Nijmeijer, Hein Gooszen, Henri G D Leuvenink, Rutger J Ploeg, and Vincent B Nieuwenhuijs.
    • Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands.
    • J. Am. Coll. Surg.. 2014 Jan 1;218(1):26-32.

    BackgroundAcute pancreatitis is a severe condition that requires early identification of patients at risk of developing potentially lethal complications. Current clinical scoring systems and biochemical parameters are insufficient. In this study, we aimed to assess whether early plasma Angiopoietin-2 (Ang-2) is associated with adverse outcomes in patients with predicted severe acute pancreatitis (SAP).Study DesignThis analysis is a substudy of the PROPATRIA trial (probiotics vs placebo in patients with predicted SAP). The Ang-2 levels were measured prospectively in plasma in the first 5 days after admission in 115 patients.ResultsEarly Ang-2 levels were higher in patients who developed SAP: 6.4 vs 3.1 μg/L (p < 0.001) and also were higher in patients who developed multiorgan failure in the first week (p = 0.001) and after the first week (p = 0.049). Furthermore, high Ang-2 levels were associated with infectious complications in the first week (p < 0.001) and after the first week (p < 0.001). Finally, plasma Ang-2 was significantly higher in patients who died (p < 0.001) and in patients who developed bowel ischemia (p < 0.001). As a predictor of adverse outcomes, plasma Ang-2 was superior to a number of current scores, such as the APACHE II score, the Imrie score, C-reactive protein, lipopolysaccharide binding protein, and procalcitonin.ConclusionsIn the setting of this randomized controlled trial, early plasma Ang-2 was found to be an accurate predictor of SAP, multiorgan failure, and infectious complications. As a biomarker, it did outperform all of the investigated conventional predictors that are currently used in clinical practice.Copyright © 2014 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

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