• Int. J. Antimicrob. Agents · May 2003

    Randomized Controlled Trial Comparative Study Clinical Trial

    Comparative analysis of azithromycin and ciprofloxacin in the treatment of chronic prostatitis caused by Chlamydia trachomatis.

    • Visnja Skerk, Slavko Schönwald, Ivan Krhen, Arthur Banaszak, Josip Begovac, Jadranka Strugar, Zvonimir Strapac, Renata Vrsalovic, Jacinta Vukovic, and Margita Tomas.
    • Dr. Fran Mihaljevic University Hospital for Infectious Diseases, Mirogojska 8, 10 000 Zagreb, Croatia. bfm@bfm.hr
    • Int. J. Antimicrob. Agents. 2003 May 1; 21 (5): 457-62.

    AbstractA total of 89 patients, (>18 years), with symptoms of chronic prostatitis and inflammatory findings as well as the presence of Chlamydia trachomatis confirmed by DNA/RNA DIGENE hybridization method and/or by isolation, McCoy culture and Lugol stain in expressed prostatic secretion or in voided bladder urine collected immediately after prostatic massage, were examined. The patients were randomized to receive a total of 4.5 g of azithromycin for 3 weeks, given as a 3-day therapy of 1 x 500 mg weekly or ciprofloxacin 500 mg b.i.d. for 20 days. Patients' sexual partners were treated at the same time. Clinical and bacteriological efficacy were evaluated 4-6 weeks after the end of therapy. Significantly higher eradication (36/45: 17/44; P=0.0002) and a significantly higher clinical cure (31/45: 15/44; P=0.0021) were achieved in the group of patients treated with azithromycin than in the ciprofloxacin group.

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