• Medicina · May 2021

    Review

    Donor-Derived Cell-Free DNA (ddcf-DNA) and Acute Antibody-Mediated Rejection in Kidney Transplantation.

    • Vishal Jaikaransingh and Pradeep V Kadambi.
    • Department of Medicine, Division of Nephrology, University of Florida, 655 West 8th Street, C290, Jacksonville, FL 32209, USA.
    • Medicina (Kaunas). 2021 May 1; 57 (5).

    AbstractMonitoring kidney transplant recipients for evidence of allograft rejection is essential to lower the risk of graft loss. The traditional method relies on serial checks in serum creatinine with a biopsy of the allograft if dysfunction is suspected. This is invasive, labor-intensive and costly. As such, there is widespread interest in the use of biomarkers to provide a noninvasive approach to detecting allograft rejection. One such biomarker is donor-derived cell-free DNA (ddcf-DNA). Here, we review the methodology for the determination of the amount/fraction of ddcf-DNA, evaluate the available data of its use in kidney transplantation and render an opinion in the clinical decision-making of these patients.

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