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Surg. Oncol. Clin. N. Am. · Oct 2020
ReviewMediastinal Germ Cell Tumors: Updates in Diagnosis and Management.
- Amanda R Stram and Kenneth A Kesler.
- Department of Surgery, Division of Cardiothoracic Surgery, Indiana University Melvin and Bren Simon Cancer Center, 545 Barnhill Drive, Indianapolis, IN 46202, USA; Department of Surgery, Thoracic Surgery Division, Indiana University, 545 Barnhill Drive, Indianapolis, IN 46202, USA.
- Surg. Oncol. Clin. N. Am. 2020 Oct 1; 29 (4): 571-579.
AbstractPrimary mediastinal nonseminomatous germ cell tumors represent a rare but important malignancy that occurs in otherwise young and healthy patients. Treatment is challenging and involves cisplatin-based chemotherapy followed by surgery to remove residual disease. Avoiding bleomycin-containing chemotherapy in the treatment of primary mediastinal nonseminomatous germ cell tumors is important. Prechemotherapy and postchemotherapy pathology as well as postoperative serum tumor markers are independent predictors of long-term survival.Copyright © 2020 Elsevier Inc. All rights reserved.
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