• J Hematol Oncol · Jun 2016

    Review

    Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma.

    • Larysa Sanchez, Yucai Wang, David S Siegel, and Michael L Wang.
    • Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
    • J Hematol Oncol. 2016 Jun 30; 9 (1): 51.

    AbstractDaratumumab is a human monoclonal antibody that targets CD38, a cell surface protein that is overexpressed on multiple myeloma (MM) cells. Preclinical studies have shown that daratumumab induces MM cell death through several mechanisms, including complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and apoptosis. Given the encouraging efficacy and acceptable safety profile of daratumumab demonstrated in clinical trials, daratumumab has emerged as a novel treatment option for myeloma and became the first monoclonal antibody approved by the FDA for the treatment of MM.

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