• I A Stepanov, V A Beloborodov, V E Borisov, M A Aliev, V V Shepelev, and Yu Ya Pestryakov.
• Irkutsk State Medical University of the Ministry of Health of Russia, Irkutsk, Russia.
• Khirurgiia (Mosk). 2020 Jan 1 (6): 60-70.

ObjectiveTo perform a meta-analysis of studies examining the effectiveness of the local application of vancomycin powder for the prophylaxis of surgical site infections (SSIs) in spine surgery.Material And MethodsRetrospective cohort studies and prospective randomized clinical trials were searched for in the Pubmed, EMBASE, Cochrane Library and eLibrary databases published from 2008 to December 2018. For the resulting variables, the odds ratio and 95% confidence interval were calculated using random and fixed effects models. Estimation of the degree of heterogeneity is estimated using the coefficient I2. Statistically significant differences were considered differences p<0.05.ResultsThe meta-analysis included 28 clinical studies that included the results of the local application of vancomycin powder in 17,469 patients after performing various spinal surgical interventions. Two publications had a prospective, randomized, controlled study design. Topical application of vancomycin powder reduces the incidence of SSIs after spine surgery (p<0.0001). The use of vancomycin powder reduces the incidence of SSIs in patients operated on with stabilizing implants (p=0.004). On the other hand, the topical application of vancomycin powder did not affect the prevalence of SSIs in respondents who were operated on without the use of stabilizing implants (p=0.12) or due to deformities of the spine (p=0.06).ConclusionTopical application of vancomycin powder is highly effective in preventing the development of SSIs in patients after spinal surgical interventions.

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