• Gerusinete Rodrigues Bastos Dos Santos, Francisca Bruna Arruda Aragão, Walder Jansen de Mello Lobão, Fabiano Rosário Lima, Luísa Marillac Ramos Lacerda de Andrade, Quesia Rodrigues Furtado, and José Eduardo Batista.
• Master in Adult and Child Health, Federal University of Maranhão (UFMA), São Luís, MA, Brasil.
• Rev Assoc Med Bras (1992). 2018 Jul 1; 64 (7): 635-642.

Aimthe present study analysed the association between Zika-virus and microcephaly during the gestational period of women in Brazil.MethodologySystematic reviews of intervention research, current publications of clinical investigations were used systematic search strategies in three electronic databases PubMed, SciELO and Google academic. The following keywords were used: Microcephaly, gestation, Zika-virus to perform the search, and 1020 articles were obtained after exclusion, 45 were left and 35 were eligible. The collection period was from 2004 to 2017.ResultsEpidemiological data suggest a temporal association between the quantitative increase and the Zika-virus epidemic, especially in Northeast Brazil. It is not consensual to measure the cephalic perimeter curve to be considered.ConclusionGiven this, the application of techniques to accurately diagnose the relationship between causes and effects in the pathogenesis of Zika virus infection in the central nervous system should be prioritized.

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